Karine Clément

Karine Clément

Article(s) publié(s) dans l’eBook:

 
Karine Clément (INSERM NutriOmique)

Prof Karine Clément is full professor of Nutrition, Division of Cardiometabolism, Pitié-Salpêtrière university hospital, Paris 6 Pierre et Marie Curie university, Paris. Since 2011, she is director of the Institute de CardiometAbolism and Nutrition (ICAN) dedicated to innovative Care, Research and training in the field of Cardiology and metabolic diseases. This institute aims at developing personalized medicine in the field of cardiometabolic diseases. During her MD, PhD in Endocrinology, metabolism and Nutrition, she has been involved in genetic and functional genomics aspects of human obesity. Her work led to the identification of monogenic forms of obesity (Leptin receptor and MC4R mutations) and to genetic risk factors in common obesities. Then, she performed a post-doctoral fellowship at Stanford University, CA, USA where she acquired competencies in gene profiling approaches applied to complex diseases (1999-2000), and in 2001, obtained a “Avenir” INSERM team before the creation of an INSERM/UPMC called NutriOmics “Nutrition and obesity Systemic approaches”; grouping different expertise (metabolism, nutrition, physiology, bioinformatics). She contributed to more than 250 international publications, reviews and many international conferences in the field (h-Index 61). Her research team showed notably that inflammatory and remodeling genes (i.e. profibrotic genes) in human adipose tissue are modulated by weight variation in parallel to changes in immune cells. The team was the first to demonstrate the accumulation of fibrosis in human adipose tissue. Deeper insights into mechanisms have been undertaken by exploring cross-talks between adipose and stroma-vascular cells (immune and non immune) and between adipocytes/ adipose tissue and muscle cell/ atria. Her research team is exploring the link between environmental changes, systemic changes and functional modifications in the adipose tissue. Many clinical studies are conducted in her group particularly in bariatric surgery model. The gut microbiota is of evidence a key actor of this link. She is a member and expert of several national and international scientific committees in obesity and metabolism and contributes to several European Networks in genetics and functional genomics (Diogenes, Hepadip, ADAPT, FLIP and coordinates METACARDIS at INSERM). Web site: http://www.ican-institute.org/team/umr_s872team-7-nutriomics-nutrition-obesity-systemic-approaches/

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